Pleiotropic Roles of S100A12 in Coronary Atherosclerotic Plaque Formation and Rupture

Human Immunodeficiency Virus (HIV) and Coronary Atherosclerotic Plaque Formation: A Review

Atherosclerotic Plaque Rupture

The idiom “the straw that breaks the camel’s back” describes scenarios where seemingly minor incidents eventuate in a sudden, unexpected, and often detrimental downfall. In the case of atherosclerosis, over time multiple subclinical cellular events result in the development of unstable, vulnerable atherosclerotic lesions, which leads to the rupture of atherosclerotic plaques, culminating in the...

Atherosclerotic Plaque Rupture

It is generally established that the unstable plaque is the major cause of acute clinical sequelae of atherosclerosis. Unfortunately, terms indicating lesions prone to plaque instability, such as “vulnerable plaque,” and the different phenotypes of unstable plaques, such as plaque rupture, plaque fissuring, intraplaque hemorrhage, and erosion, are often used interchangeably. Moreover, the diffe...

4 Atherosclerotic plaque rupture

The arterial system is more than an intricate plumbing system for the transport of blood; it is a highly complex organ that interacts with its environment. The major function of the vessel wall, and more specifically the endothelial lining, is to maintain an adequate blood supply to the end organ that it is supplying. This is achieved by regulatory mechanisms that control vascular tone, inflamm...

Multiple atherosclerotic plaque rupture in acute coronary syndrome.

Coronary Syndrome To the Editor: In their interesting article, Rioufol et al1 found that patients with acute coronary syndromes frequently had findings on intravascular ultrasound (IVUS) of ruptured plaques in coronary arteries remote from the artery with the culprit lesion. They use this as evidence that there is a period of overall instability throughout the coronary vasculature at the time o...